People aging with HIV infection (PAWH) experience greater impairments in physical and cognitive function, in addition to higher rates of peripheral comorbid conditions (e.g. renal failure, diabetes, bone fracture, hypertension, cardiovascular disease, polypharmacy and multimorbidity). While multifactorial drivers including HIV infection itself, antiretroviral therapy (ART)-related toxicities, disparities in care and biobehavioral factors likely contribute, there remains an overarching question as what are the relevant age-related mechanisms and models that could inform interventions that promote healthspan and lifespan in PAWH? This workshop was convened to hear from experts on the biology of aging and HIV researchers studying PAWH to focus on advancing investigation at the interface of HIV and Aging. Here we summarize the discussions from the Harvard Center for AIDS Research and Boston Claude D. Pepper co-sponsored workshop on HIV and Aging, which took place in October of 2018.