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• Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
• Persistent Low-Level Replication of SIVnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
• CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVnef-induced protection.
• CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.