Wong

Latest

• Persistent Low-Level Replication of SIVnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
• CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVnef-induced protection.
• SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa.
• Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection.
• Quantification of mucosal mononuclear cells in tissues with a fluorescent bead-based polychromatic flow cytometry assay.
• CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.