Keele

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• Intestinal damage precedes mucosal immune dysfunction in SIV infection.
• Persistent Low-Level Replication of SIVnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
• Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.