Johnson

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• Persistent Low-Level Replication of SIVnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
• Characterization of CD8+ T cell differentiation following SIVnef vaccination by transcription factor expression profiling.
• CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVnef-induced protection.
• Transcriptional profiling of peripheral CD8+T cell responses to SIVnef and SIVmac251 challenge reveals a link between protective immunity and induction of systemic immunoregulatory mechanisms.
• Live simian immunodeficiency virus vaccine correlate of protection: local antibody production and concentration on the path of virus entry.
• NK cell responses to simian immunodeficiency virus vaginal exposure in naive and vaccinated rhesus macaques.
• Location and dynamics of the immunodominant CD8 T cell response to SIVnef immunization and SIVmac251 vaginal challenge.
• Monkeypox virus infection of rhesus macaques induces massive expansion of natural killer cells but suppresses natural killer cell functions.
• Multi-functional plasmacytoid dendritic cells redistribute to gut tissues during simian immunodeficiency virus infection.
• No monkey business: why studying NK cells in non-human primates pays off.
• ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge.
• SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa.
• Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection.
• Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques.
• Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.
• Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.
• KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
• Potential confusion of contaminating CD16+ myeloid DCs with anergic CD16+ NK cells in chimpanzees.
• Quantification of mucosal mononuclear cells in tissues with a fluorescent bead-based polychromatic flow cytometry assay.
• Simian immunodeficiency virus infection induces expansion of alpha4beta7+ and cytotoxic CD56+ NK cells.
• CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.
• Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.