Gillis

Latest

• Persistent Low-Level Replication of SIVnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
• CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVnef-induced protection.
• Bone marrow-imprinted gut-homing of plasmacytoid dendritic cells (pDCs) in acute simian immunodeficiency virus infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae.
• Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
• Multi-functional plasmacytoid dendritic cells redistribute to gut tissues during simian immunodeficiency virus infection.
• SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa.
• Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection.
• Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.
• Quantification of mucosal mononuclear cells in tissues with a fluorescent bead-based polychromatic flow cytometry assay.
• Simian immunodeficiency virus infection induces expansion of alpha4beta7+ and cytotoxic CD56+ NK cells.
• CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.