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• Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
• Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.
• KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
• Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza.
• A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples.
• Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance.
• MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction.
• Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection.